Briefly, poloxamer 407 basf, ludwigshafen, germany was added to 0. Formulation and characterization of rivastigmine loaded. It exhibits excellent abrasion resistance, toughness, transparency, very good low temperature. Then, the impact of poloxamer 407 concentration on gel formation was evaluated. We are the preferred supplier for your skin delivery solutions. Among the poloxamers, poloxamer 407 with registered trademarks of pluronic f127 by basf laboratories and. A 32 full factorial experiment was designed to study the effect of independent. The versatile melamine resin foam basf construction north. List of drug master files dmf of ibuprofen active pharmaceutical ingredient api submitted to the u. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Poloxamer as an excipient authorstream presentation.
Poloxamer 407 has approximate block lengths of a 101 and b 56. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Topical hydrogels of gentamicin were produced using poloxamer 407 and polyacrlic acids. Basf corporation evaluation of lutrol f grades prill vs. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj introduction lutrol f grades are block copolymers referred to as poloxamers, consisting of polyoxyethylene. Coronary occlusion techniques during opcab may lead to an endothelial damage to the target vessel. Basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorization. Effects of temporary vascular occluder poloxamer 407 gel on. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties.
Strategy focused on participating in fast growing asian markets. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. In the present study, we explored the potential of rivastigmine loaded solid lipid nanoparticle sln, as a new formulation in improving the bioavailability of antialzheimer drug rivastigmine which otherwise reported with poor bioavailability. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. Nov 17, 2014 melting point nonproprietry name melting point c poloxamer 124 16 poloxamer 188 5257 poloxamer 237 49 poloxamer 338 57 poloxamer 407 5257 28. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. Based on its pkpd ratios, doxycycline hyclate doxh, a timedependant antibacterial, is ideally expected to achieve both sustained plasma drug concentrations at or slightly above the mic level for as long as possible between dosing intervals. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations kolliphor p 407 is also used as a polymeric solubilizer. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of functional applications. We are committed to maintaining the highest level of quality across the product spectrum.
Journal of orthopaedic surgery and research effect of poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model soungyon kim 0 soowon chae juneyoung lee 0 department of orthopaedic surgery, hallym university kangnam sacred heart hospital, 9481, daerim1 dong, yeongdeungpogu, seoul 150950, south korea background. Rheology modifiers pdf, 859 kb rheology modifiers product recommendations for asia pacific pdf, 171 kb rheology modifiers product recommendations for europe pdf, 532 kb rheology modifiers product recommendations for north america pdf, 183 kb. Yes, i would like to contribute to a better webbrowsing experience. You can find detailed information on our product range by looking up your industry or using our product finder. Elastollan tpu technical data sheet elastollan 1185a polyetherbased grade elastollan 1185a is specifically formulated for extruded profile, sheet and film applications. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. For protection from shear stress, poloxamer 188 has a long publication history as well as documented use in the manufacturing of approved biologics. Pdf poloxamers, also known as pluronics, are block copolymers of. Moisture content poloxamers generally contain less than 0. Basf to develop a high purity poloxamer for mast therapeutics.
It exhibits excellent abrasion resistance, toughness, transparency, very good low temperature flexibility, hydrolytic stability and fungus resistance. Effect of poloxamer 407 as a carrier vehicle on rotator cuff. If you have further question, click the link below to send us an email. The approximate lengths of the two peg blocks is 101 repeat units while the approximate length of the propylene.
The ease of production, the stability at 4 c or at room temperature and the low cost of the formulation, when compared to the phospholipids used in the liposomal formulations, are attractive conditions. Pursuing this end, a poloxamer based matrix was used to produce a longacting injectable preparation doxhla and its serum concentrations vs. Basf, poloxamer 407 and poloxamer 188 being the most widely used in the literature. Publication of wo2009055312a1 publication critical patentwo2009055312a1en. Password please note our services have been updated. Higher molecular weight poloxamer has the ability to form thermoreversible gels. Assessment of transdermal penetration enhancement by topical. Poloxamer complete drug information, side effects and. With over 50 years experience in eopo chemistry, basf is committed to providing kolliphor p 188 bio, which is designed to meet your needs in quality, consistency, and performance in cell culture systems. Poloxamer 407 pluronic f127 has been applied in a very broad range in biomedical and pharmaceutical industries torchilin et al.
Download brochures this page features a selection of our latest brochures. In vivo studies showing the effects of biologic healing. In particular poloxamer 407 lutrol f127 has been used in a number of applications, including ocular drug delivery7,8, where the increase in viscosity at body temperature increases the residence time of the drug on the eye. The adverse effects of these techniques are wellknown, and researches have been trying to find out new materials to occlude the coronary artery without an endothelial damage. The sales representative responsible for your area will be happy to answer any questions you may have about our products. Pluracare f127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications. Us20274421a1 highly pure poloxamers and purification. Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. Poloxamer is a common biopolymer in intradermal drugdelivery. In addition to poloxamer 188 nf, basf also offers comprehensive solutions to the pharmaceutical industry for both small and large molecule formulation needs. The only monographed poloxamer that is liquid at room temperature making it ideal for liquid dosage forms. English pdf, 627 kb superb foam with the pu fixed poker from basf. Humidity induced phase transformation of poloxamer 188 and. Us drug master file basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorizations.
Download fulltext pdf poloxamer hydrogels for biomedical applications article pdf available in pharmaceutics 1112. A supercritical fluid extraction process was used to prepare p188p. The only monographed poloxamer that is liquid at room temperature making it. Poloxamers and poloxamines are examples of biocompat.
Flexible excipient to overcome a wide range of pharmaceutical challenges that. Pharmacokinetics of an injectable longacting formulation. Pursuing this end, a poloxamerbased matrix was used to produce a longacting injectable preparation doxhla and its serum concentrations vs. Flexible excipient to overcome a wide range of pharmaceutical challenges that provide formulators with. Thermogelling properties of purified poloxamer 407 sciencedirect. Development of in situ poloxamerchitosan hydrogels for vaginal. Differential effects of commercialgrade and purified. The components of poloxamer 188 solution basf is specialised in intermediates for rigid polyurethane foam and spray coatings for a multitude of applications. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor.
Quarterly statement pdf annual shareholders meeting 2020. For example, the gelation temperature of poloxamer 407 is about 25 c and the gelation is affected by poloxamer grade. Basf maintains a drug master file for poloxamers at the fda and is familiar with supplying. Pdf poloxamers, poloxamines and polymeric micelles. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene polypropylene oxide flanked by two hydrophilic chains of polyoxyethylene polyethylene oxide.
In vitro biological activity, toxicity and in vivo therapeutic efficacy against murine tegumentary leishmaniasis. Incorporating simvastatinpoloxamer 407 hydrogel into 3d. There is a possibility that this would work better than injections. Ibuprofen api dmfs us drug master file dmf details.
Kolliphor p 407 is used primarily as thickening agent and gel former, as well as coemulsifier and consistency enhancer in creams and liquid emulsions. The impurities of commercial grade poloxamer 188, as an example. Article information, pdf download for safety assessment of poloxamers 101, 105, 108. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. Assessment of transdermal penetration enhancement by. It possesses solubilizing, bodying and gelling properties. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. Despite their wide range of applications, limited analytical techniques have been reported in literature for characterizing poloxamers and few are. Process for producing a poloxamer gel download pdf. Poloxamer 407 is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. Basf s unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type. The poloxamer 407 hydrogels were prepared as previously described. Data on pluronic polyols, basf wyandotte corporation, herein incorporated by reference. Basf maintains a drug master file for poloxamers at the fda and is familiar with.
Learn about poloxamer from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Basf pharma ingredients and services offers our solutionsoriented skin delivery platform to formulators of otc and rx topical. Pharmacokinetics of an injectable longacting formulation of. Nonetheless, this important physical property of poloxamer 188 should be made available to pharmaceutical researchers as part of the risk assessment when using poloxamer 188 in formulation development. It is a surfactant functioning both as cleansing and solubilizing agent. Poloxamer 188, european pharmacopoeia ep reference standard. Evaluation of hydrogels based on poloxamer 407 and polyacrylic.
Pdf formulation of poloxamers for drug delivery researchgate. If you decide to use photos or graphics belonging to inge gmbh, please clearly indicate this fact in the list of references or the image caption. Poloxamers are also known by the trade names synperonics. The micrioemulsion based method was adopted for preparation of sln.
Basf pharmaceuticalgrade ingredients for the dermatology industry. Basf poloxamers offer better solubilizing properties compared to hpmc, pvp and. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c. Definition, structure and therapeutic applications in cancer. With over 50 years experience in eopo chemistry, basf is committed to providing the poloxamer kolliphor p 188 bio, which is designed to meet your needs in quality, consistency, and performance. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181. Wo2009055312a1 process for producing a poloxamer gel. Poloxamer 407 pluronic f127based polymeric micelles for. Trends and formulation strategies for topical drugs. In the present study, we investigate to the endothelial damage in the rat aorta which is occluded by poloxamer 407 gel.
German pdf, 6 mb english pdf, 6 mb chemistry creates versatility. Ferguson recreation center in florida, usa, is using basfs melamine foam basotect to enhance acoustics for swimmers and visitors. Effect of poloxamer 407 as a carrier vehicle on rotator. Effects of temporary vascular occluder poloxamer 407 gel. Fagron wants to widen the therapeutic scope of the. Effect of poloxamer 407 as a carrier vehicle on rotator cuff healing in a rat model. No, please bring me to the brochure download page now. Pdf poloxamer hydrogels for biomedical applications. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer.
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